RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease

J Allergy Clin Immunol. 2016 Mar;137(3):960-3. doi: 10.1016/j.jaci.2015.09.048. Epub 2015 Nov 21.
No abstract available

Publication types

  • Letter

MeSH terms

  • Arthritis / drug therapy
  • Arthritis / genetics
  • Arthritis / immunology*
  • Arthritis / metabolism
  • Gene Expression Regulation / drug effects
  • Humans
  • Indazoles / chemistry
  • Indazoles / pharmacology*
  • Inflammatory Bowel Diseases / drug therapy
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / metabolism
  • Interleukin-17 / biosynthesis
  • Nuclear Receptor Subfamily 1, Group F, Member 3 / antagonists & inhibitors*
  • T-Lymphocyte Subsets / drug effects
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism
  • Th17 Cells / drug effects*
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism

Substances

  • Indazoles
  • Interleukin-17
  • MRL-248
  • MRL-367
  • Nuclear Receptor Subfamily 1, Group F, Member 3