Clinical significance of IL-2 and IL-10 gene polymorphisms and serum levels in patients with basal-cell carcinoma

Biomark Med. 2016;10(2):185-95. doi: 10.2217/bmm.15.113. Epub 2015 Nov 26.

Abstract

Materials & methods: Polymorphic variants of IL-2 gene (-330 T/G and +166 G/T), IL-10 gene (-1082 G/A and -819 C/T) and serum cytokines concentrations in the group of 179 patients with BCC and 173 controls were analyzed.

Results: The presence of the IL-2 -330 GG genotype or IL-10 -1082 GA increased the risk of BCC (OR 3.68) (OR 3.07). IL-10 -1082 AA or GA and IL-2 -330 GG genotype increased the risk of BCC (OR 9.63). IL-2 serum levels were significantly lower (p < 0.0004) in BCC patients while IL-10 concentration was significantly higher (p < 0.00001).

Conclusion: The polymorphisms in IL-2 and IL-10 genes may contribute to BCC susceptibility and influence the clinical course of BCC in polish population.

Keywords: BC; IL-10; IL-2; basal-cell carcinoma; gene polymorphism; interleukin serum concentrations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Basal Cell / blood*
  • Carcinoma, Basal Cell / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-10 / blood*
  • Interleukin-10 / genetics*
  • Interleukin-2 / blood*
  • Interleukin-2 / genetics*
  • Male
  • Middle Aged
  • Poland / epidemiology
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Skin Neoplasms / blood*
  • Skin Neoplasms / genetics*
  • White People / genetics

Substances

  • IL10 protein, human
  • IL2 protein, human
  • Interleukin-2
  • Interleukin-10