microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1)

Wei Dai; Hai-Li Huang; Min Hu; Si-Jie Wang; Hui-Juan He; Nian-Pin Chen; Ming-Yi Li

microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1)

Am J Cancer Res. 2015 Aug 15;5(9):2697-707. eCollection 2015.

Authors

Wei Dai¹, Hai-Li Huang², Min Hu¹, Si-Jie Wang², Hui-Juan He², Nian-Pin Chen¹, Ming-Yi Li¹

Affiliations

¹ Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.
² Clinical Research Center, The Affiliated Hospital of Guangdong Medical College 524001 Zhanjiang, China.

PMID: 26609477
PMCID: PMC4633899

Abstract

Our previous study indicates microRNA-506 (miR-506) is downregulated in hepatocellular carcinoma (HCC). In the current study, we investigate the effects of miR-506 on proliferation, migration and invasion in HCC. We report that enforced expression of miR-506 inhibits proliferation, migration and invasion in vitro, and suppresses tumor growth in vivo. Conversely, suppression of miR-506 exhibits promoting effects on proliferation, migration and invasion in vitro, and on tumor growth in vivo. In addition, miR-506 binds to the 3'UTR of F-spondin 1(SPON1), and enforced expression of miR-506 decreases accumulation of SPON1. Moreover, enforced expression of SPON1 and suppression of SPON1 alleviates effects of miR-506 mimics and inhibitors on proliferation, migration and invasion in vitro, respectively. In conclusion, microRNA-506 regulates proliferation, migration and invasion in HCC by targeting SPON1.

Keywords: SPON1; hepatocellular carcinoma; microRNA-506; migration and invasion; proliferation.