Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast

Ther Deliv. 2015;6(10):1195-210. doi: 10.4155/tde.15.68. Epub 2015 Oct 8.

Abstract

Background: A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging.

Methods & results: A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3O4) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region.

Conclusion: This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Intravenous
  • Animals
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / drug therapy
  • Cell Line, Tumor
  • Contrast Media / administration & dosage
  • Female
  • Hypothermia, Induced / methods*
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles / administration & dosage*
  • Mice
  • Mice, Inbred BALB C
  • Polyethylene Glycols / administration & dosage*
  • Surface Properties

Substances

  • Contrast Media
  • Magnetite Nanoparticles
  • Polyethylene Glycols