Abstract
Copper-catalyzed reactions of glycine ester arylimines and methacrylonitrile provide selective access to either the endo or exo pyrrolidine cycloadducts. DFT calculations have elucidated the origins of ligand-controlled diastereoselectivity.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Azo Compounds / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Copper / chemistry
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Cycloaddition Reaction
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Glycine / analogs & derivatives
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Glycine / chemistry
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Ligands
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Methacrylates / chemistry*
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Molecular Structure
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Nitriles / chemistry*
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Pyrrolidines / chemical synthesis
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Pyrrolidines / chemistry
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Stereoisomerism
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Thiosemicarbazones / chemistry*
Substances
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Azo Compounds
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Ligands
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Methacrylates
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Nitriles
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Pyrrolidines
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Thiosemicarbazones
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azomethine
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methacrylonitrile
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Copper
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Glycine