1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
2 The Keenan Research Centre for Biomedical Science, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, Canada M5B 1W8 Departments of Surgery and Physiology, University of Toronto, Toronto, ON, Canada Institute of Physiology, Charité - Universitaetsmedizin Berlin, Berlin, Germany German Heart Institute Berlin, Berlin, Germany kueblerw@smh.ca.