Metastatic saccrococcygeal chordoma

J Clin Neurosci. 2016 Jan:23:149-152. doi: 10.1016/j.jocn.2015.05.036. Epub 2015 Nov 18.

Abstract

We report a 46-year-old man who presented with a 2week history of worsening headaches and acute onset left sided hemiplegia. He had undergone a surgical resection of a sacral chordoma 13years prior, followed by adjuvant radiotherapy and chemotherapy. MRI revealed multiple enhancing lesions in the brain, and the two largest were resected. The histopathology was consistent with chordoma. Sacrococcygeal chordomas are locally invasive notochord-related sarcomas. They rarely metastasize to the brain, and only eight patients have been reported. While currently available adjuvant radiotherapy and systemic chemotherapeutic regimens can be implemented in the management of these rare patients, they have shown limited success. The newer strategies that are reported here have also been disappointing.

Keywords: Brain metastases; Cerebral metastases; Sacrococcygeal chordomas.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / surgery
  • Chordoma / diagnosis*
  • Chordoma / surgery
  • Coccyx / pathology*
  • Coccyx / surgery
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • Sacrum / pathology*
  • Sacrum / surgery
  • Spinal Neoplasms / diagnosis*
  • Spinal Neoplasms / surgery