The Repeatability Assessment of Three-Dimensional Capsule-Intraocular Lens Complex Measurements by Means of High-Speed Swept-Source Optical Coherence Tomography

PLoS One. 2015 Nov 23;10(11):e0142556. doi: 10.1371/journal.pone.0142556. eCollection 2015.

Abstract

Purpose: To rebuild the three-dimensional (3-D) model of the anterior segment by high-speed swept-source optical coherence tomography (SSOCT) and evaluate the repeatability of measurement for the parameters of capsule-intraocular lens (C-IOL) complex.

Methods: Twenty-two pseudophakic eyes from 22 patients were enrolled. Three continuous SSOCT measurements were performed in all eyes and the tomograms obtained were used for 3-D reconstruction. The output data were used to evaluate the measurement repeatability. The parameters included postoperative aqueous depth (PAD), the area and diameter of the anterior capsule opening (Area and D), IOL tilt (IOL-T), horizontal, vertical, and space decentration of the IOL, anterior capsule opening, and IOL-anterior capsule opening.

Results: PAD, IOL-T, Area, D, and all decentration measurements showed high repeatability. Repeated measure analysis showed there was no statistically significant difference among the three continuous measurements (all P > .05). Pearson correlation analysis showed high correlation between each pair of them (all r >0.90, P<0.001). ICCs were all more than 0.9 for all parameters. The 95% LoAs of all parameters were narrow for comparison of three measurements, which showed high repeatability for three measurements.

Conclusion: SSOCT is available to be a new method for the 3-D measurement of C-IOL complex after cataract surgery. This method presented high repeatability in measuring the parameters of the C-IOL complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Algorithms
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Lens Capsule, Crystalline / pathology*
  • Lens Implantation, Intraocular / methods*
  • Lenses, Intraocular*
  • Middle Aged
  • Phacoemulsification / methods*
  • Postoperative Complications
  • Refraction, Ocular
  • Reproducibility of Results
  • Software
  • Tomography, Optical Coherence / methods*

Grants and funding

This study was supported by research grants from Foundation of National Nature Science Foundation of China (Grant No. 80213050 to Yun-e Zhao); and Zhejiang Provincial Natural Science Foundation of China (LY13H120005 to JL). The contribution of the G.B. Fondazione Bietti IRCCS in this paper was supported by the Italian Ministry of Health and by Fondazione Roma. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.