[Ovarian failure: New treatments in perspective?]

Abstract

The premature loss of ovarian function may have physical and psychological consequences. A better understanding of its mechanism is therefore needed. Because they are affecting the oocyte quality, the decline of the ovarian reserve and high maternal age are implicated in many defects leading to chromosomal defects, modifications of gene expression or alterations of the mitochondrial pattern of the oocyte. However, cellular therapies such as ovarian follicle activation or isolation of ovarian stem cells are promising treatments of ovarian failure.

Keywords: Activation folliculaire; Cellules souches; Fertility; Fertilité; Follicle activation; Genetics; Génétique; Insuffisance ovarienne; Ovarian failure; Stem cells.