Spinal metastases: Is stereotactic body radiation therapy supported by evidences?

Crit Rev Oncol Hematol. 2016 Feb:98:147-58. doi: 10.1016/j.critrevonc.2015.11.002. Epub 2015 Nov 10.

Abstract

Stereotactic body radiotherapy (SBRT) is becoming widely adopted in the treatment of primary and secondary tumors. Spinal bone metastases are frequently discovered in cancer patients, and in the past have been usually treated with a palliative goal. Nevertheless, in some particular clinical settings, such as oligometastatic patients and/or those with a long life expectancy, spinal SBRT could be considered a valid therapeutic option to obtain long-lasting palliation and, when possible, with a curative goal. This review aims to summarize available clinical and dosimetric data of published studies about spinal SBRT.

Keywords: Dosimetry; Local control; Palliative radiotherapy; SBRT; Spine metastases; Toxicity.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / epidemiology
  • Bone Neoplasms / secondary
  • Bone Neoplasms / surgery
  • Evidence-Based Practice / standards
  • Evidence-Based Practice / statistics & numerical data
  • Fractures, Compression / epidemiology
  • Fractures, Compression / etiology
  • Fractures, Compression / pathology
  • Humans
  • Palliative Care
  • Radiosurgery* / adverse effects
  • Radiosurgery* / statistics & numerical data
  • Radiotherapy Dosage
  • Spinal Fractures / epidemiology
  • Spinal Fractures / etiology
  • Spinal Fractures / pathology
  • Spinal Neoplasms / epidemiology
  • Spinal Neoplasms / secondary*
  • Spinal Neoplasms / surgery*
  • Treatment Outcome