Abstract
A phytochemical investigation of the crude extracts of the bark and leaves of Calophyllum symingtonianum has resulted in the isolation of inophyllum D, inophyllum H, calanone, isocordato-oblongic acid, amentoflavone, carpachromene and lupenone. Their chemical structures were elucidated and confirmed by spectroscopic analysis. All flavonoids and coumarins showed significant α-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arachidonate 15-Lipoxygenase / metabolism*
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Calophyllum / chemistry*
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Glycoside Hydrolase Inhibitors / pharmacology*
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Lipoxygenase Inhibitors / chemistry
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Lipoxygenase Inhibitors / pharmacology*
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Molecular Structure
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Phytochemicals / chemistry
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Phytochemicals / pharmacology*
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Plant Bark / chemistry
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Plant Leaves / chemistry
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alpha-Glucosidases / metabolism*
Substances
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Glycoside Hydrolase Inhibitors
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Lipoxygenase Inhibitors
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Phytochemicals
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Arachidonate 15-Lipoxygenase
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alpha-Glucosidases