α-Glucosidase and 15-Lipoxygenase Inhibitory Activities of Phytochemicals from Calophyllum symingtonianum

Nat Prod Commun. 2015 Sep;10(9):1585-7.

Abstract

A phytochemical investigation of the crude extracts of the bark and leaves of Calophyllum symingtonianum has resulted in the isolation of inophyllum D, inophyllum H, calanone, isocordato-oblongic acid, amentoflavone, carpachromene and lupenone. Their chemical structures were elucidated and confirmed by spectroscopic analysis. All flavonoids and coumarins showed significant α-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arachidonate 15-Lipoxygenase / metabolism*
  • Calophyllum / chemistry*
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Lipoxygenase Inhibitors / chemistry
  • Lipoxygenase Inhibitors / pharmacology*
  • Molecular Structure
  • Phytochemicals / chemistry
  • Phytochemicals / pharmacology*
  • Plant Bark / chemistry
  • Plant Leaves / chemistry
  • alpha-Glucosidases / metabolism*

Substances

  • Glycoside Hydrolase Inhibitors
  • Lipoxygenase Inhibitors
  • Phytochemicals
  • Arachidonate 15-Lipoxygenase
  • alpha-Glucosidases