Abstract
Serjania goniocarpa is a plant used in Mayan traditional medicine as a remedy for the treatment of cancer-like symptoms. Bio-guided fractionation of the methanol extract of the leaves led to the isolation of an α- and β-amyrin mixture, palmitic acid, phytol and the new sesterterpene goniocarpic acid whose structure was elucidated by IR, GC-MS, and NMR spectroscopic analyses. Goniocarpic acid exhibited cytotoxic and antiproliferative activity against several cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Humans
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Medicine, Traditional
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Molecular Structure
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Plant Extracts / chemistry
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Plant Leaves / chemistry
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Sapindaceae / chemistry*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification*
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Sesterterpenes / chemistry*
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Sesterterpenes / isolation & purification*
Substances
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Plant Extracts
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Sesquiterpenes
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Sesterterpenes
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goniocarpic acid
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Oleanolic Acid
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beta-amyrin