Crystal structure of 2-fluoro-N-(1,3-thia-zol-2-yl)benzamide

Rodolfo Moreno-Fuquen; Juan C Castillo; Diana Becerra; Hernando Camargo; José A Henao

doi:10.1107/S2056989015019192

Crystal structure of 2-fluoro-N-(1,3-thia-zol-2-yl)benzamide

Acta Crystallogr E Crystallogr Commun. 2015 Oct 24;71(Pt 11):o882-3. doi: 10.1107/S2056989015019192. eCollection 2015 Nov 1.

Authors

Rodolfo Moreno-Fuquen¹, Juan C Castillo², Diana Becerra¹, Hernando Camargo³, José A Henao⁴

Affiliations

¹ Departamento de Química - Facultad de Ciencias Naturales y Exactas, Universidad del Valle, Apartado 25360, Santiago de Cali, Colombia.
² Departamento de Química, Universidad de los Andes, Carrera 1 No 18A12, Bogotá, Colombia.
³ Facultad de Química Ambiental, Universidad Santo Tomás, Campus Universitario Floridablanca, Santander, Colombia.
⁴ Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, Apartado 678, Bucaramanga, Colombia.

Abstract

In the title compound, C10H7FN2OS, the mean plane of the central amide fragment (r.m.s. deviation = 0.048 Å) makes dihedral angles of 35.28 (8) and 10.14 (12)° with those of the fluoro-benzene and thia-zole rings, respectively. The thia-zole S and amide O atoms lie to the same side of the mol-ecule. In the crystal, pairs of N-H⋯N hydrogen bonds connect the mol-ecules into inversion dimers with R 2 (2)(8) motifs, and weak C-H⋯O inter-actions connect the mol-ecules into C(6) [001] chains. Together, the N-H⋯N and C-H⋯O hydrogen bonds generate (100) sheets.

Keywords: 1,3-thiazole; benzamide; cancer cell-growth inhibitors; carboxamides; crystal structure; hydrogen bonding; thiazole derivatives.