Abstract
The synthesis of acyclic cucurbit[n]uril dendrimers G1-G3 that bear four dendrons on their aromatic sidewalls via thiolate S(N)2 chemistry is reported. G1-G3 are polycationic and can bind to pEGFP plasmid DNA as shown by dynamic light scattering (DLS), gel electrophoresis, and scanning electron microscopy (SEM). The gene delivery ability of G1-G3 is presented.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Dendrimers / chemical synthesis*
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Dendrimers / chemistry
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Gene Transfer Techniques
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Macrocyclic Compounds / chemical synthesis*
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Macrocyclic Compounds / chemistry
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Microscopy, Electron, Scanning
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Molecular Structure
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Plasmids / genetics
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Polyamines / chemistry
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Polyelectrolytes
Substances
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Dendrimers
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Macrocyclic Compounds
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Polyamines
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Polyelectrolytes
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cucurbit(n)uril
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polycations