Flavanones of Erythrina livingstoniana with antioxidant properties

Kibrom Gebreheiwot Bedane; Souvik Kusari; Ishmael B Masesane; Michael Spiteller; Runner R T Majinda

doi:10.1016/j.fitote.2015.11.014

Flavanones of Erythrina livingstoniana with antioxidant properties

Fitoterapia. 2016 Jan:108:48-54. doi: 10.1016/j.fitote.2015.11.014. Epub 2015 Nov 17.

Authors

Kibrom Gebreheiwot Bedane¹, Souvik Kusari², Ishmael B Masesane³, Michael Spiteller⁴, Runner R T Majinda⁵

Affiliations

¹ Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany.
² Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany.
³ Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
⁴ Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221, Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.
⁵ Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana. Electronic address: majindar@mopipi.ub.bw.

PMID: 26592853
DOI: 10.1016/j.fitote.2015.11.014

Abstract

Six new flavanones (1-6), together with six known compounds were isolated from Erythrina livingstoniana. Their structures were elucidated on the basis of NMR data and HRMS(n) fragmentation pathway and by comparison with literature data. Compounds 5, 7 and 8 showed remarkable DPPH free radical scavenging efficacies. The compounds, however, did not demonstrate an anti-inflammatory potential when tested using a PGE2 (prostaglandin E2) competitive enzyme immunoassay. The plausible biosynthetic pathways of the isolated compounds are described.

Keywords: Erylivingstone D–I; Erythrina livingstoniana; Fabaceae; Flavanone; HRMS(n); NMR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dinoprostone
Erythrina / chemistry*
Flavanones / chemistry*
Flavanones / isolation & purification
Free Radical Scavengers / chemistry*
Free Radical Scavengers / isolation & purification
Molecular Structure
Plant Extracts / chemistry

Substances

Flavanones
Free Radical Scavengers
Plant Extracts
Dinoprostone