Role of intestinal microbiota in transplantation outcomes

Best Pract Res Clin Haematol. 2015 Jun-Sep;28(2-3):155-61. doi: 10.1016/j.beha.2015.10.013. Epub 2015 Oct 22.

Abstract

While allogeneic hematopoietic stem cell transplantations have a curative potential, infections and graft-versus-host disease remain significant problems. The intestinal microbiota can influence responses to cancer chemotherapy and the role of the microbiota in affecting allogeneic hematopoietic stem cell transplantation outcomes is increasingly appreciated. The following paper discusses the most recent developments in this area.

Trial registration: ClinicalTrials.gov NCT02269150.

Keywords: Allo-HSCT; Bacteremia; Diversity; Intestinal microbiota; Metronidazole; Microbial dominance; Mortality; Survival.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Bacteremia / drug therapy*
  • Bacteremia / etiology
  • Bacteremia / microbiology
  • Bacteremia / mortality
  • Clinical Trials as Topic
  • Gastrointestinal Microbiome*
  • Graft vs Host Disease / microbiology
  • Graft vs Host Disease / mortality
  • Graft vs Host Disease / pathology
  • Graft vs Host Disease / prevention & control*
  • Hematologic Neoplasms / microbiology
  • Hematologic Neoplasms / mortality
  • Hematologic Neoplasms / pathology
  • Hematologic Neoplasms / therapy*
  • Hematopoietic Stem Cell Transplantation / mortality*
  • Humans
  • Metronidazole / administration & dosage
  • Metronidazole / adverse effects
  • Opportunistic Infections / drug therapy*
  • Opportunistic Infections / etiology
  • Opportunistic Infections / microbiology
  • Opportunistic Infections / mortality
  • Risk Factors
  • Survival Analysis
  • Vancomycin / administration & dosage
  • Vancomycin / adverse effects
  • Vancomycin-Resistant Enterococci / growth & development
  • Vancomycin-Resistant Enterococci / pathogenicity

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Metronidazole
  • Vancomycin

Associated data

  • ClinicalTrials.gov/NCT02269150