Potent Antibody Protection against an Emerging Alphavirus Threat

Margaret Kielian; Erica Ollmann Saphire

doi:10.1016/j.cell.2015.11.006

Potent Antibody Protection against an Emerging Alphavirus Threat

Cell. 2015 Nov 19;163(5):1053-1054. doi: 10.1016/j.cell.2015.11.006.

Authors

Margaret Kielian¹, Erica Ollmann Saphire²

Affiliations

¹ Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: margaret.kielian@einstein.yu.edu.
² Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: erica@scripps.edu.

PMID: 26590413
DOI: 10.1016/j.cell.2015.11.006

Abstract

Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.

Publication types

Comment

MeSH terms

Alphavirus / immunology*
Alphavirus Infections / immunology*
Animals
Antibodies, Monoclonal / immunology*
Antibodies, Neutralizing / immunology*
Antibodies, Viral / immunology*
Epitopes*
Humans
Viral Envelope Proteins / immunology*

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
Antibodies, Viral
Epitopes
Viral Envelope Proteins

Grants and funding

R01 AI075647/AI/NIAID NIH HHS/United States