TAILS N-terminomic and proteomic datasets of healthy human dental pulp

Ulrich Eckhard; Giada Marino; Simon R Abbey; Ian Matthew; Christopher M Overall

doi:10.1016/j.dib.2015.10.003

TAILS N-terminomic and proteomic datasets of healthy human dental pulp

Data Brief. 2015 Oct 16:5:542-8. doi: 10.1016/j.dib.2015.10.003. eCollection 2015 Dec.

Authors

Ulrich Eckhard¹, Giada Marino¹, Simon R Abbey¹, Ian Matthew², Christopher M Overall³

Affiliations

¹ Centre for Blood Research, The Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada ; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
² Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
³ Centre for Blood Research, The Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada ; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada ; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Abstract

The Data described here provide the in depth proteomic assessment of the human dental pulp proteome and N-terminome (Eckhard et al., 2015) [1]. A total of 9 human dental pulps were processed and analyzed by the positional proteomics technique TAILS (Terminal Amine Isotopic Labeling of Substrates) N-terminomics. 38 liquid chromatography tandem mass spectrometry (LC-MS/MS) datasets were collected and analyzed using four database search engines in combination with statistical downstream evaluation, to yield the by far largest proteomic and N-terminomic dataset of any dental tissue to date. The raw mass spectrometry data and the corresponding metadata have been deposited in ProteomeXchange with the PXD identifier <PXD002264>; Supplementary Tables described in this article are available via Mendeley Data (10.17632/555j3kk4sw.1).

Keywords: Human dental pulp; N-terminome; Proteome; TAILS N-terminomics; Tandem mass spectrometry.