Successful management of the mangled extremity is difficult; however, recent advancements are changing the outcomes of these difficult cases. Multiple centers are working on new bionic limbs with real-time feedback and better performance parameters. Research progress, particularly in the military sector, has aided in our understanding of heterotopic ossification after devastating limb injuries. This progress has also allowed a better treatment program for the residual limb in surgery and postsurgery. It is an exciting time in the management and rehabilitation of amputated limbs, as both biologic and technological advancements are enabling better patient satisfaction. This article looks at some of these discoveries and how they are changing the treatment of the residual limb.