Elispot Igra With Purified Protein Derivative Stimulation For Diagnosing Nontuberculous Mycobacterial Cervical Lympadenitis

Antti Kontturi; Tamara Tuuminen; Riitta Karttunen; Eeva Salo

doi:10.1097/INF.0000000000000998

Elispot Igra With Purified Protein Derivative Stimulation For Diagnosing Nontuberculous Mycobacterial Cervical Lympadenitis

Pediatr Infect Dis J. 2016 Mar;35(3):349-51. doi: 10.1097/INF.0000000000000998.

Authors

Antti Kontturi¹, Tamara Tuuminen, Riitta Karttunen, Eeva Salo

Affiliation

¹ From the *Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki; †Eastern Finland Laboratory Centre Joint Authority Enterprise (ISLAB), Mikkeli District Laboratory, Mikkeli; ‡Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki; and §Laboratory Division (HUSLAB), Helsinki University Central Hospital, Helsinki, Finland.

PMID: 26584055
DOI: 10.1097/INF.0000000000000998

Abstract

Childhood cervical lymphadenitis caused by nontuberculous mycobacteria is a diagnostic challenge for the clinician. We present a new promising diagnostic method for childhood nontuberculous mycobacterial lymphadenitis. The modified T-SPOT.TB test with purified protein derivative as an additional antigen is noninvasive with estimated sensitivity and specificity of 1.00 and 0.81, respectively.

MeSH terms

Biopsy
Case-Control Studies
Child, Preschool
Enzyme-Linked Immunospot Assay / methods*
Female
Finland
Humans
Infant
Lymph Nodes / microbiology
Lymph Nodes / pathology
Lymphadenitis / diagnosis*
Lymphadenitis / immunology*
Lymphadenitis / microbiology
Male
Mycobacterium Infections, Nontuberculous / diagnosis*
Mycobacterium Infections, Nontuberculous / immunology*
Mycobacterium Infections, Nontuberculous / microbiology
Nontuberculous Mycobacteria / immunology*