TCM, brain function and drug space

Chunping Tang; Yang Ye; Yunjiang Feng; Ronald J Quinn

doi:10.1039/c5np00049a

TCM, brain function and drug space

Nat Prod Rep. 2016 Jan;33(1):6-25. doi: 10.1039/c5np00049a.

Authors

Chunping Tang¹, Yang Ye², Yunjiang Feng³, Ronald J Quinn³

Affiliations

¹ Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. r.quinn@griffith.edu.au and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China and Eskitis-SIMM Joint Laboratory for Drug Discovery, Australia.
³ Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. r.quinn@griffith.edu.au and Eskitis-SIMM Joint Laboratory for Drug Discovery, Australia.

PMID: 26583936
DOI: 10.1039/c5np00049a

Abstract

Covering: up to 2015. Traditional Chinese medicine has played a significant role in the mainstream healthcare system in China for thousands of years. Here, we summarize 84 major compounds from 15 selected herbal medicines targeting neurodegenerative diseases. We present a perspective based on the analysis of physicochemical properties of these TCM compounds, and comparison with current drugs and candidates for the treatment of Parkinson's and Alzheimer's disease. The results demonstrate that traditional Chinese medicines contain compounds possessing physicochemical properties that have excellent overlap with developed western medicines.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / drug therapy
Brain / physiopathology*
Humans
Medicine, Chinese Traditional*
Molecular Structure
Parkinson Disease / drug therapy
Plants, Medicinal / chemistry*