Abstract
Combining metformin with exercise has been proposed to improve glucose homeostasis. However, we primarily discuss evidence suggesting that metformin and other pharmacological agents/dietary supplements (e.g., statins, resveratol, or antioxidants) may in fact oppose exercise-induced benefits on insulin sensitivity and cardiometabolic health. We explore the novel hypothesis that attenuation of oxidative stress from exercise by these exogenous compounds blunts metabolic adaptation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Blood Glucose / metabolism
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Cardiovascular Diseases / prevention & control
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Diabetes Mellitus, Type 2 / blood*
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / therapy*
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Diabetic Angiopathies / prevention & control
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Exercise Therapy*
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Humans
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Hypoglycemic Agents / therapeutic use*
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Insulin Resistance
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Metformin / therapeutic use*
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Oxidative Stress
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Physical Fitness
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Risk Factors
Substances
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Blood Glucose
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Hypoglycemic Agents
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Metformin