Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Acta Derm Venereol. 2016 May;96(4):525-9. doi: 10.2340/00015555-2295.

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on long-term sequelae in patients admitted for SJS, SJS/TEN overlap, or TEN between 1998 and 2012. Among all 102 patients eligible for analysis, the 2 most common sequelae were cutaneous and ocular problems, both with incidences of 44.1%. Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / epidemiology*
  • Eye Diseases / diagnosis
  • Eye Diseases / epidemiology*
  • Female
  • Hashimoto Disease / epidemiology
  • Humans
  • Incidence
  • Lung Diseases, Interstitial / epidemiology
  • Lupus Erythematosus, Systemic / epidemiology
  • Male
  • Middle Aged
  • Prognosis
  • Renal Insufficiency, Chronic / epidemiology
  • Retrospective Studies
  • Sjogren's Syndrome / epidemiology
  • Skin Diseases / diagnosis
  • Skin Diseases / epidemiology*
  • Stevens-Johnson Syndrome / diagnosis
  • Stevens-Johnson Syndrome / epidemiology*
  • Stevens-Johnson Syndrome / therapy
  • Taiwan / epidemiology
  • Time Factors