Interleukin-10 production at the early stage of infection with foot-and-mouth disease virus related to the likelihood of persistent infection in cattle

Vet Res. 2015 Nov 19:46:132. doi: 10.1186/s13567-015-0276-y.

Abstract

The factors leading to persistent infection of foot-and-mouth disease (FMD) virus in ruminants are not well defined. This paper provides evidence of the presence of interleukin-10 (IL-10) early in the course of infection (1-4 days) as a factor in the development of persistence of FMD virus in cattle. Results showed that serum IL-10 in carrier cattle infected with FMD virus type O (n = 4) was detected and peaked at 1 or 2 days post infection and rapidly declined thereafter. In contract, serum IL-10 levels in non-carrier cattle (n = 21) were very low or undetectable during the same period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Cattle Diseases / immunology*
  • Cattle Diseases / virology
  • Foot-and-Mouth Disease / immunology*
  • Foot-and-Mouth Disease / virology
  • Foot-and-Mouth Disease Virus / genetics
  • Foot-and-Mouth Disease Virus / physiology*
  • Interferons / blood*
  • Interleukin-10 / blood*

Substances

  • Interleukin-10
  • Interferons