Antiviral sesquiterpenes from leaves of Nicotiana tabacum

Fitoterapia. 2016 Jan:108:1-4. doi: 10.1016/j.fitote.2015.11.004. Epub 2015 Nov 12.

Abstract

Three unreported sesquiterpenes possessing two new skeletons, tabasesquiterpenes A-C (1-3), together with three known sesquiterpenes (3-6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 2 exhibited high anti-TMV activity with inhibition rate of 35.2%, which were higher than that of positive control (ningnanmycin). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 20.5-28.6%.

Keywords: Anti-tobacco mosaic virus activity; Nicotiana tabacum; Sesquiterpenes; Tabasesquiterpenes A–C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Molecular Structure
  • Nicotiana / chemistry*
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Tobacco Mosaic Virus / drug effects*

Substances

  • Antiviral Agents
  • Plant Extracts
  • Sesquiterpenes