Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

Zhenfang Zhou; Xin Wang; Hui Zhang; Jingya Sun; Linghui Zheng; Hongchun Liu; Jidong Wang; Aijun Shen; Meiyu Geng; Yuewei Guo

doi:10.1016/j.apsb.2014.11.001

Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

Acta Pharm Sin B. 2015 Jan;5(1):62-6. doi: 10.1016/j.apsb.2014.11.001. Epub 2015 Jan 7.

Authors

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
² Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China.

Abstract

A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K α radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC50 values of 7.7, 7.0, and 16.5 nmol/L, respectively.

Keywords: Absolute configuration; Bacterium; Chromobacterium sp.; Chromopeptide A; Cytotoxicity; Depsipeptide; Marine-derived; Sediments.