Spontaneous remission in three cases of AML M5 with NPM1 mutation

Vincent Camus; Pascaline Etancelin; Fabrice Jardin; Pascal Lenain; Nathalie Contentin; Sylvie Daliphard; Gérard Buchonnet; Emilie Lemasle; Hélène Lanic; Stéphane Leprêtre; Dominique Penther; Sydney Dubois; Hervé Tilly; Christian Bastard; Aspasia Stamatoullas

doi:10.1002/ccr3.408

Spontaneous remission in three cases of AML M5 with NPM1 mutation

Clin Case Rep. 2015 Nov;3(11):955-9. doi: 10.1002/ccr3.408. Epub 2015 Oct 21.

Authors

Affiliations

¹ Department of Haematology, Centre Henri Becquerel Rue d'Amiens, 76038, Rouen, France ; INSERM U918, Centre Henri Becquerel Rue d'Amiens, 76038, Rouen, France.
² INSERM U918, Centre Henri Becquerel Rue d'Amiens, 76038, Rouen, France ; Department of Genetic Oncology, Centre Henri Becquerel Rue d'Amiens, 76038, Rouen, France.
³ Department of Haematology, Centre Henri Becquerel Rue d'Amiens, 76038, Rouen, France.
⁴ Department of Biological Haematology, Charles Nicolle University Hospital 76000, Rouen, France.
⁵ Department of Genetic Oncology, Centre Henri Becquerel Rue d'Amiens, 76038, Rouen, France.

Abstract

Patients with NPM1-mutated AML M5 who develop spontaneous remission (SR) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of AML M5 patients with the same genotype that experienced transient SR and are now leukemia free after standard treatment.

Keywords: NPM1 mutation; acute myeloid leukemia; monocytic leukemia; spontaneous remission.

Publication types

Case Reports