Abstract
We describe the genome of a penicillinase-producing Kingella kingae strain (KWG1), the first to be isolated in continental Europe, whose bla(TEM-1) gene was, for the first time in this species, found to be chromosomally inserted. The bla(TEM) gene is located in an integrative and conjugative element (ICE) inserted in Met-tRNA and comprising genes that encode resistance to sulfonamides, streptomycin, and tetracycline. This ICE is homologous to resistance-conferring plasmids of K. kingae and other Gram-negative bacteria.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Chromosome Mapping
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Chromosomes, Bacterial / chemistry*
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Drug Resistance, Bacterial / genetics
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Gene Expression Regulation, Bacterial*
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Gene Ontology
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Genome, Bacterial*
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Humans
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Kingella kingae / drug effects
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Kingella kingae / genetics*
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Kingella kingae / isolation & purification
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Kingella kingae / metabolism
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Molecular Sequence Annotation
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Neisseriaceae Infections / microbiology
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Plasmids / chemistry
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Plasmids / metabolism
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Streptomycin / pharmacology
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Sulfonamides / pharmacology
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Tetracycline / pharmacology
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Sulfonamides
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beta-Lactamases
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Tetracycline
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Streptomycin