Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology

Klaas E Stephan; Elisabeth B Binder; Michael Breakspear; Peter Dayan; Eve C Johnstone; Andreas Meyer-Lindenberg; Ulrich Schnyder; Xiao-Jing Wang; Dominik R Bach; Paul C Fletcher; Jonathan Flint; Michael J Frank; Andreas Heinz; Quentin J M Huys; P Read Montague; Michael J Owen; Karl J Friston

doi:10.1016/S2215-0366(15)00360-0

Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology

Lancet Psychiatry. 2016 Jan;3(1):84-90. doi: 10.1016/S2215-0366(15)00360-0. Epub 2015 Nov 11.

Authors

Klaas E Stephan¹, Elisabeth B Binder², Michael Breakspear³, Peter Dayan⁴, Eve C Johnstone⁵, Andreas Meyer-Lindenberg⁶, Ulrich Schnyder⁷, Xiao-Jing Wang⁸, Dominik R Bach⁹, Paul C Fletcher¹⁰, Jonathan Flint¹¹, Michael J Frank¹², Andreas Heinz¹³, Quentin J M Huys¹⁴, P Read Montague¹⁵, Michael J Owen¹⁶, Karl J Friston¹⁷

Affiliations

¹ Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland; ETH Zurich, Zurich, Switzerland; The Wellcome Trust Centre for Neuroimaging, University College London, London, UK; Max Planck Institute for Metabolism Research, Cologne, Germany. Electronic address: stephan@biomed.ee.ethz.ch.
² Deptartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
³ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Metro North Mental Health Service, Brisbane, Australia.
⁴ Gatsby Computational Neuroscience Unit, University College London, London, UK.
⁵ Department of Psychiatry, University of Edinburgh, Edinburgh, UK.
⁶ Central Institute of Mental Health, University of Mannheim, Mannheim, Germany.
⁷ Department of Psychiatry and Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁸ Center for Neural Science, New York University, New York, NY, USA; Institute of Brain and Cognitive Science, NYU Shanghai, Shanghai, China.
⁹ Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland; The Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
¹⁰ Department of Psychiatry, University of Cambridge, Cambridge, UK.
¹¹ The Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK.
¹² Brown Institute for Brain Science, Brown University, Providence, RI, USA.
¹³ Department of Psychiatry, Humboldt University Berlin, Berlin, Germany.
¹⁴ Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital of Psychiatry, University of Zurich, Zurich, Switzerland; ETH Zurich, Zurich, Switzerland.
¹⁵ The Wellcome Trust Centre for Neuroimaging, University College London, London, UK; Computational Psychiatry Unit, Virginia Tech Carilion Research Institute, Roanoke, VA, USA.
¹⁶ MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK; Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
¹⁷ The Wellcome Trust Centre for Neuroimaging, University College London, London, UK.

PMID: 26573969
DOI: 10.1016/S2215-0366(15)00360-0

Abstract

This is the second of two companion papers proposing priority problems for research on mental disorders. Whereas the first paper focuses on questions of nosology and diagnosis, this Personal View concerns pathogenesis and aetiology of psychiatric diseases. We hope that this (non-exhaustive and subjective) list of problems, nominated by scientists and clinicians from different fields and institutions, provides guidance and perspectives for choosing future directions in psychiatric science.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Humans
Mental Disorders / etiology*
Mental Disorders / pathology*
Psychiatry*
Research*

Abstract

Publication types

MeSH terms

Grants and funding