Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage

Pamela B Cassidy; Zalfa A Abdel-Malek; Sancy A Leachman

doi:10.1038/jid.2015.349

Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage

J Invest Dermatol. 2015 Dec;135(12):2918-2921. doi: 10.1038/jid.2015.349.

Authors

Pamela B Cassidy¹, Zalfa A Abdel-Malek², Sancy A Leachman³

Affiliations

¹ Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
² Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
³ Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: leachmas@ohsu.edu.

Abstract

Scientists at the University of Kentucky are unraveling the details of DNA-damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al., (2015, this issue) report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).

Publication types

Comment

MeSH terms

DNA Repair*
Humans
Melanocytes / metabolism*
Receptor, Melanocortin, Type 1 / physiology*

Substances

Receptor, Melanocortin, Type 1

Abstract

Publication types

MeSH terms

Substances

Grants and funding