Gonadal Function and Fertility Among Survivors of Childhood Cancer

Zoltan Antal; Charles A Sklar

doi:10.1016/j.ecl.2015.08.002

Gonadal Function and Fertility Among Survivors of Childhood Cancer

Endocrinol Metab Clin North Am. 2015 Dec;44(4):739-49. doi: 10.1016/j.ecl.2015.08.002. Epub 2015 Sep 15.

Authors

Zoltan Antal¹, Charles A Sklar²

Affiliations

¹ Department of Pediatric Endocrinology, New York Presbyterian Hospital, Weill Cornell Medical College, 505 East 70 Street, New York, NY 10021, USA; Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
² Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: sklarc@mskcc.org.

PMID: 26568489
DOI: 10.1016/j.ecl.2015.08.002

Abstract

Reproductive health and fertility are of great importance to the increasing number of survivors of childhood cancer, approximately 70% of whom are estimated to be over 20 years old. This article reviews the various treatment exposures that have been associated with makers of gonadal injury and decreased fertility in childhood cancer survivors. Identifying risk factors that decrease fertility is essential in proper counseling and timely referral for interventions that may allow for future fertility in high-risk populations.

Keywords: Chemotherapy; Childhood cancer survivor; Fertility; Gonadal injury; Infertility; Pregnancy; Radiation.

Publication types

Review

MeSH terms

Antineoplastic Agents, Alkylating / adverse effects*
Child
Humans
Infertility* / chemically induced
Infertility* / etiology
Neoplasms* / drug therapy
Neoplasms* / radiotherapy
Radiotherapy / adverse effects*
Survivors*

Substances

Antineoplastic Agents, Alkylating