Abstract
A copper-mediated radiofluorination of aryl- and vinylboronic acids with K(18)F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [(18)F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Boronic Acids / chemistry*
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Catalysis
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Copper / chemistry*
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Fluorine Radioisotopes / chemistry*
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Molecular Structure
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Nitriles / chemical synthesis*
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Nitriles / chemistry
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Positron-Emission Tomography
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
Substances
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3-fluoro-5-((pyridin-3-yl)ethynyl)benzonitrile
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Boronic Acids
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Fluorine Radioisotopes
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Nitriles
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Pyridines
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Radiopharmaceuticals
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Copper