A universal tumor cell isolation method enabled by fibrin-coated microchannels

Jinling Zhang; Z Hugh Fan

doi:10.1039/c5an01783a

A universal tumor cell isolation method enabled by fibrin-coated microchannels

Analyst. 2016 Jan 21;141(2):563-6. doi: 10.1039/c5an01783a.

Authors

Jinling Zhang¹, Z Hugh Fan²

Affiliations

¹ Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, Florida 32611, USA. hfan@ufl.edu.
² Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, Florida 32611, USA. hfan@ufl.edu and J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, P.O. Box 116131, Gainesville, FL 32611, USA.

Abstract

We report a simple but effective strategy to capture tumor cells using fibrin-immobilized microchannels. It is a universal method since it shows an ability to capture both epithelial and mesenchymal tumor cells. The cell capture efficiency is up to 90%.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Separation / instrumentation
Cell Separation / methods*
Fibrin / chemistry*
Humans
Lab-On-A-Chip Devices*
Neoplastic Cells, Circulating / chemistry
Neoplastic Cells, Circulating / pathology

Substances

Fibrin

Abstract

Publication types

MeSH terms

Substances

Grants and funding