Smart Pipette and Microfluidic Pipette Tip for Blood Plasma Separation

Byeongyeon Kim; Sungyoung Choi

doi:10.1002/smll.201502719

Smart Pipette and Microfluidic Pipette Tip for Blood Plasma Separation

Small. 2016 Jan 13;12(2):190-7. doi: 10.1002/smll.201502719. Epub 2015 Nov 16.

Authors

Byeongyeon Kim¹, Sungyoung Choi¹

Affiliation

¹ Department of Biomedical Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do, 446-701, Republic of Korea.

PMID: 26568206
DOI: 10.1002/smll.201502719

Abstract

An integrated method for blood plasma separation is presented by combining a pneumatic device, which is referred to as a "smart pipette," and a hydrophoretic microchannel as a microfluidic pipette tip for whole-blood sample preparation. This method enables hemolysis-free, high-purity plasma separation through smart pipetting of whole blood, potentially providing the means for rapid, inexpensive blood sample preparation for point-of-care testing.

Keywords: blood plasma separation; hydrophoresis; microfluidic pipette tips; microfluidics; smart pipettes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dogs
Erythrocytes / cytology
Microfluidics / instrumentation*
Microfluidics / methods*
Plasma / chemistry*
Pressure