Antioxidants, Enzyme Inhibitors, and Biogenic Compounds in Grain Extracts of Barleys

Chem Biodivers. 2015 Nov;12(11):1678-95. doi: 10.1002/cbdv.201400419.

Abstract

The content of biogenic compounds and the biological activities of barley (Hordeum vulgare L.)-grain extracts was evaluated. The sufficiently large and heterogeneous set of barley genotypes (100 accessions) enabled the selection of special genotypes interesting for potential industrial, pharmaceutical, and medicinal applications. Barley genotypes with the highest contents of phenols, phenolic acids, flavonoids, biogenic thiols, and amines, radical-scavenging activity, as well as inhibitory activities of trypsin, thrombin, collagenase, urokinase, and cyclooxygenase were identified.

Keywords: Antioxidant; Barley; Cluster analysis (CA); Flavonoids; Grain extract; Hordeum vulgare; Phenols; Principal component analysis (PCA); Protease inhibitor; Radical-scavenging activity.

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Collagenases / metabolism
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Genotype
  • Hordeum / chemistry*
  • Hordeum / genetics
  • Humans
  • Plant Extracts / chemistry*
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Structure-Activity Relationship
  • Thrombin / antagonists & inhibitors
  • Thrombin / metabolism
  • Trypsin / metabolism
  • Urokinase-Type Plasminogen Activator / antagonists & inhibitors
  • Urokinase-Type Plasminogen Activator / metabolism

Substances

  • Antioxidants
  • Enzyme Inhibitors
  • Plant Extracts
  • Prostaglandin-Endoperoxide Synthases
  • Trypsin
  • Thrombin
  • Urokinase-Type Plasminogen Activator
  • Collagenases