Antibiotic Education: Not Just Another Brick in the Cell Wall

Inka Sastalla; Sandip K Datta

doi:10.1016/j.chom.2015.10.019

Antibiotic Education: Not Just Another Brick in the Cell Wall

Cell Host Microbe. 2015 Nov 11;18(5):520-2. doi: 10.1016/j.chom.2015.10.019.

Authors

Inka Sastalla¹, Sandip K Datta²

Affiliations

¹ Bacterial Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
² Bacterial Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: dattas@niaid.nih.gov.

PMID: 26567505
DOI: 10.1016/j.chom.2015.10.019

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) are resistant to β-lactam antibiotics, which inhibit bacterial cell wall synthesis. In this issue of Cell Host & Microbe, Müller et al. (2015) show that β-lactam treatment of MRSA leads to synthesis of an altered cell wall that increases inflammasome activation and immunopathology during skin infection.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Anti-Bacterial Agents / pharmacology*
Cell Wall
Methicillin-Resistant Staphylococcus aureus*
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents

Grants and funding

Intramural NIH HHS/United States