Drug sensitivity testing platforms for gastric cancer diagnostics

Vianne Lau; Andrea Li-Ann Wong; Christopher Ng; Yingting Mok; Manikandan Lakshmanan; Benedict Yan

doi:10.1136/jclinpath-2015-203426

Drug sensitivity testing platforms for gastric cancer diagnostics

J Clin Pathol. 2016 Feb;69(2):93-6. doi: 10.1136/jclinpath-2015-203426. Epub 2015 Nov 13.

Authors

Vianne Lau¹, Andrea Li-Ann Wong², Christopher Ng³, Yingting Mok⁴, Manikandan Lakshmanan⁵, Benedict Yan³

Affiliations

¹ Department of Gastroenterology Monash University, Melbourne, Australia.
² Department of Haematology and Oncology, National University Health System, Singapore, Singapore.
³ Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore Department of Laboratory Medicine, Molecular Diagnosis Centre, National University Hospital, National University Health System, Singapore, Singapore.
⁴ Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore.
⁵ Mouse Models for Human Cancer Unit, Institute of Molecular and Cell Biology, Singapore, Singapore.

PMID: 26567318
DOI: 10.1136/jclinpath-2015-203426

Abstract

Gastric cancer diagnostics has traditionally been histomorphological and primarily the domain of surgical pathologists. Although there is an increasing usage of molecular and genomic techniques for clinical diagnostics, there is an emerging field of personalised drug sensitivity testing. In this review, we describe the various personalised drug sensitivity testing platforms and discuss the challenges facing clinical adoption of these assays for gastric cancer.

Keywords: CHEMOTHERAPY; CIRCULATING TUMOUR CELLS; GASTRIC CANCER.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Drug Screening Assays, Antitumor / methods*
Genetic Predisposition to Disease
Humans
Mice
Molecular Diagnostic Techniques*
Molecular Targeted Therapy*
Neoplastic Cells, Circulating / drug effects
Neoplastic Cells, Circulating / metabolism
Neoplastic Cells, Circulating / pathology
Phenotype
Precision Medicine / methods*
Predictive Value of Tests
Prognosis
Reproducibility of Results
Signal Transduction / drug effects
Stomach Neoplasms / drug therapy*
Stomach Neoplasms / genetics*
Stomach Neoplasms / metabolism
Stomach Neoplasms / pathology
Tumor Cells, Cultured
Xenograft Model Antitumor Assays

Substances

Antineoplastic Agents
Biomarkers, Tumor