Changes in reproductive physiology of mangrove rivulus Kryptolebias marmoratus following exposure to environmentally relevant doses of ethinyl oestradiol

J Fish Biol. 2016 Feb;88(2):774-86. doi: 10.1111/jfb.12814. Epub 2015 Nov 12.

Abstract

Kryptolebias marmoratus exposed to 4 ng l(-1) of ethinyl oestradiol (EE2) for 30 days experienced significant changes in endogenous 17β-oestradiol (E2) and 11-ketotestosterone (KT) and qualitative changes in gonad morphology. Both hermaphrodites and males showed a significant decrease in E2, whereas only males exhibited a significant decrease in KT. Exposure to EE2 resulted in a decrease in spermatid and spermatocyte density in males and an increase in the number of early stage oocytes in hermaphrodites.

Keywords: 11-ketotestosterone; 17β-oestradiol; endocrine disruption; fish; gonad morphology; reproduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Endocrine Disruptors / toxicity*
  • Environment
  • Estradiol / blood
  • Ethinyl Estradiol / toxicity*
  • Female
  • Gonads / drug effects*
  • Hermaphroditic Organisms / physiology
  • Killifishes / physiology*
  • Male
  • Oocytes / drug effects
  • Reproduction / drug effects*
  • Spermatids / drug effects
  • Spermatocytes / drug effects
  • Testosterone / analogs & derivatives
  • Testosterone / blood

Substances

  • Endocrine Disruptors
  • Testosterone
  • Ethinyl Estradiol
  • Estradiol
  • 11-ketotestosterone