High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe

Analyst. 2015 Dec 21;140(24):8097-100. doi: 10.1039/c5an01810b.

Abstract

A prototype 1 mm High-Resolution micro-Magic Angle Spinning (HRμMAS) probe is described. High quality (1)H NMR spectra were obtained from 490 μg of heterogeneous biospecimens, offering a rich-metabolite profiling. The results demonstrate the potential of HRμMAS as a new NMR analytical tool in metabolomics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biopsy / instrumentation*
  • Brain / pathology
  • Magnetic Resonance Spectroscopy*
  • Metabolomics / instrumentation*
  • Molecular Probes / chemistry

Substances

  • Molecular Probes