The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease

Mycopathologia. 2016 Apr;181(3-4):305-9. doi: 10.1007/s11046-015-9963-5. Epub 2015 Nov 13.

Abstract

A 16-year-old boy with chronic granulomatous disease presented with pneumonia and rib osteomyelitis. Emericella nidulans var. echinulata was isolated from his sputum. After starting voriconazole, Rasamsonia piperina was isolated from the rib swelling. A combination therapy of voriconazole and micafungin effectively eradicated this invasive mixed-mold infection. In immunocompromised patients, a precise pathogenic diagnosis is clinically useful for administration of an appropriate treatment regimen.

Keywords: Chronic granulomatous disease; Emericella nidulans var. echinulata; Micafungin; Rasamsonia piperina; Voriconazole.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antifungal Agents / therapeutic use*
  • Ascomycota / drug effects*
  • Ascomycota / isolation & purification
  • Coinfection / drug therapy
  • Echinocandins / therapeutic use*
  • Emericella / drug effects*
  • Emericella / isolation & purification
  • Granulomatous Disease, Chronic / microbiology*
  • Humans
  • Immunocompromised Host
  • Lipopeptides / therapeutic use*
  • Male
  • Micafungin
  • Mycoses / drug therapy*
  • Mycoses / microbiology*
  • Sputum / microbiology
  • Voriconazole / therapeutic use*

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Voriconazole
  • Micafungin