Recombinant measles AIK-C vaccine strain expressing heterologous virus antigens

Vaccine. 2016 Jan 4;34(2):292-295. doi: 10.1016/j.vaccine.2015.10.127. Epub 2015 Nov 10.

Abstract

Further attenuated measles vaccines were developed more than 50 years ago and have been used throughout the world. Recombinant measles vaccine candidates have been developed and express several heterologous virus protective antigens. Immunogenicity and protective actions were confirmed using experimental animals: transgenic mice, cotton rats, and primates. The recent development of measles vaccine-based vectored vaccine candidates has been reviewed and some information on recombinant measles vaccines expressing respiratory syncytial virus proteins has been shown and discussed.

Keywords: AIK-C measles vaccine; Recombinant virus; Respiratory syncytial virus; Reverse genetics.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / biosynthesis
  • Antigens / genetics
  • Antigens / immunology*
  • Drug Carriers*
  • Gene Expression*
  • Measles virus / genetics*
  • Mice, Transgenic
  • Primates
  • Recombinant Proteins / biosynthesis
  • Recombinant Proteins / genetics
  • Recombinant Proteins / immunology*
  • Respiratory Syncytial Virus Vaccines / genetics
  • Respiratory Syncytial Virus Vaccines / immunology*
  • Respiratory Syncytial Viruses / genetics
  • Respiratory Syncytial Viruses / immunology*
  • Sigmodontinae
  • Treatment Outcome
  • Vaccines, Attenuated / genetics
  • Vaccines, Attenuated / immunology
  • Vaccines, Synthetic / genetics
  • Vaccines, Synthetic / immunology

Substances

  • Antigens
  • Drug Carriers
  • Recombinant Proteins
  • Respiratory Syncytial Virus Vaccines
  • Vaccines, Attenuated
  • Vaccines, Synthetic