The 'Omics' of Voluntary Exercise: Systems Approaches to a Complex Phenotype

Scott A Kelly; Fernando Pardo-Manuel de Villena; Daniel Pomp

doi:10.1016/j.tem.2015.10.002

The 'Omics' of Voluntary Exercise: Systems Approaches to a Complex Phenotype

Trends Endocrinol Metab. 2015 Dec;26(12):673-675. doi: 10.1016/j.tem.2015.10.002. Epub 2015 Nov 6.

Authors

Scott A Kelly¹, Fernando Pardo-Manuel de Villena², Daniel Pomp³

Affiliations

¹ Department of Zoology, Ohio Wesleyan University, Delaware, OH 43015, USA.
² Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
³ Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: dpomp@unc.edu.

PMID: 26555601
DOI: 10.1016/j.tem.2015.10.002

Abstract

Predisposition to engage in exercise is highly variable and simultaneously influenced by the environment, complex genomics, and their interactions. Given the importance of exercise to health, understanding the underlying influences of variability is crucial. Here, we discuss murine systems approaches, focusing on 'omics', relevant to revealing the architecture of voluntary activity.

Keywords: Collaborative Cross; Diversity Outbred; genomics; proteomics; transcriptomics; wheel running.

MeSH terms

Animals
Environment
Exercise / physiology*
Genomics*
Humans
Phenotype*
Physical Conditioning, Animal / physiology*
Proteomics*

Abstract

MeSH terms

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