MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma

Longhao Sun; Corrine Ying Xuan Chua; Weijun Tian; Zhixiang Zhang; Paul J Chiao; Wei Zhang

doi:10.1016/j.jgg.2015.07.003

MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma

J Genet Genomics. 2015 Oct 20;42(10):563-577. doi: 10.1016/j.jgg.2015.07.003. Epub 2015 Aug 6.

Authors

Longhao Sun¹, Corrine Ying Xuan Chua², Weijun Tian³, Zhixiang Zhang³, Paul J Chiao⁴, Wei Zhang⁵

Affiliations

¹ Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
² Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA.
³ Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
⁴ Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA.
⁵ Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: wzhang@mdanderson.org.

PMID: 26554910
DOI: 10.1016/j.jgg.2015.07.003

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. MicroRNAs (miRNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how miRNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression.

Keywords: MicroRNA; Pancreatic ductal adenocarcinoma; Signaling pathway; Tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carcinoma, Pancreatic Ductal / genetics*
Humans
MicroRNAs / genetics*
Signal Transduction / genetics
Signal Transduction / physiology

Substances

MicroRNAs