Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

Nasim Annabi; Su Ryon Shin; Ali Tamayol; Mario Miscuglio; Mohsen Afshar Bakooshli; Alexander Assmann; Pooria Mostafalu; Jeong-Yun Sun; Suzanne Mithieux; Louis Cheung; Xiaowu Shirley Tang; Anthony S Weiss; Ali Khademhosseini

doi:10.1002/adma.201503255

Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels

Adv Mater. 2016 Jan 6;28(1):40-9. doi: 10.1002/adma.201503255. Epub 2015 Nov 9.

Authors

Nasim Annabi^{1

2

3

4}, Su Ryon Shin^{1

2

3}, Ali Tamayol^{1

2

3}, Mario Miscuglio^{1

2}, Mohsen Afshar Bakooshli^{1

2}, Alexander Assmann^{1

2

3

5}, Pooria Mostafalu^{1

2}, Jeong-Yun Sun⁶, Suzanne Mithieux⁷, Louis Cheung⁸, Xiaowu Shirley Tang⁸, Anthony S Weiss⁷, Ali Khademhosseini^{1

2

3

9}

Affiliations

¹ Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
² Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
³ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
⁴ Department of Chemical Engineering, Northeastern University, Boston, MA, 02115-5000, USA.
⁵ Department of Cardiovascular Surgery, Heinrich Heine University, 40225, Düsseldorf, Germany.
⁶ Department of Material Science and Engineering, Seoul National University, Seoul, 151-742, South Korea.
⁷ Molecular Bioscience, Charles Perkins Centre, Bosch Institute, University of Sydney, Sydney, NSW, 2006, Australia.
⁸ Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
⁹ Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.

Abstract

A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect of these two materials significantly enhances both ultimate strain (250%), reversible rotation (9700°), and the fracture energy (38.8 ± 0.8 J m(-2) ) in the hybrid network. Furthermore, improved electrical signal propagation and subsequent contraction of the muscles connected by hybrid hydrogels are observed in ex vivo tests.

Keywords: cardiac tissue engineering; elasticity; graphene oxides; hydrogels; tropoelastins.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Elasticity*
Electric Conductivity*
Engineering
Graphite / chemistry
Humans
Hydrogels / chemistry*
Models, Molecular
Molecular Conformation
Oxides / chemistry
Tensile Strength
Tropoelastin / chemistry*

Substances

Hydrogels
Oxides
Tropoelastin
Graphite

Abstract

Publication types

MeSH terms

Substances

Grants and funding