Discovering of Tumor-targeting Peptides using Bi-functional Microarray

Adv Healthc Mater. 2015 Dec 30;4(18):2802-8. doi: 10.1002/adhm.201500724. Epub 2015 Nov 9.

Abstract

A bi-functional microarray for in situ peptide screening is presented herein, from which an affinity peptide towards EpCAM is screened out for tumor cell capture.

Keywords: bi-functional; capture; circulating tumor cells; microarray; peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Neoplasm / metabolism
  • Cell Adhesion Molecules / metabolism
  • Cell Line, Tumor
  • Epithelial Cell Adhesion Molecule
  • Fluorescence
  • Humans
  • Magnetics
  • Microarray Analysis / methods*
  • Molecular Sequence Data
  • Neoplasms / drug therapy*
  • Peptides / chemistry
  • Peptides / therapeutic use*
  • Protein Binding

Substances

  • Antigens, Neoplasm
  • Cell Adhesion Molecules
  • Epithelial Cell Adhesion Molecule
  • Peptides