CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?

J Invest Dermatol. 2015 Nov;135(11):2562-2564. doi: 10.1038/jid.2015.300.

Abstract

The complex pathogenesis of psoriasis is still not fully understood. The study by Sun et al. (2015) suggests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of psoriasis, and thus targeting CCN1 represents a potential therapeutic strategy in its treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Cysteine-Rich Protein 61 / metabolism*
  • Female
  • Humans
  • Inflammation Mediators / metabolism*
  • Psoriasis / metabolism*
  • Psoriasis / pathology*

Substances

  • Cysteine-Rich Protein 61
  • Inflammation Mediators