Capillary electrophoresis in metallodrug development

Hannah Holtkamp; Christian G Hartinger

doi:10.1016/j.ddtec.2015.07.004

Capillary electrophoresis in metallodrug development

Drug Discov Today Technol. 2015 Sep:16:16-22. doi: 10.1016/j.ddtec.2015.07.004. Epub 2015 Sep 1.

Authors

Hannah Holtkamp¹, Christian G Hartinger²

Affiliations

¹ University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand.
² University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: c.hartinger@auckland.ac.nz.

PMID: 26547417
DOI: 10.1016/j.ddtec.2015.07.004

Abstract

Capillary electrophoresis (CE) is a separation method based on differential migration of analytes in electric fields. The compatibility with purely aqueous separation media makes it a versatile tool in metallodrug research. Many metallodrugs undergo ligand exchange reactions that can easily be followed with this method and the information gained can even be improved by coupling the CE to advanced detectors, such as mass spectrometers. This gives the method high potential to facilitate the development of metallodrugs, especially when combined with innovative method development and experimental design.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Coordination Complexes / analysis*
Coordination Complexes / chemistry*
Drug Discovery / methods*
Drug Discovery / trends
Electrophoresis, Capillary / methods
Humans

Substances

Coordination Complexes