Healthcare utilisation by pregnant patients with asthma in South Korea: a cohort study using nationwide claims data

BMJ Open. 2015 Nov 6;5(11):e008416. doi: 10.1136/bmjopen-2015-008416.

Abstract

Objectives: Few nationwide population-based studies have examined the burden of asthma during pregnancy. Here, we investigated the burden and medical treatment of asthma during pregnancy requiring healthcare utilisation in South Korea.

Design: Cohort study.

Setting: Nationwide insurance claims database.

Participants: A total of 1,306,281 pregnant women who delivered in South Korea in 2009-2011.

Outcomes: The prevalence and exacerbation rates of asthma requiring healthcare utilisation, and the prescription of antiasthmatic drugs during pregnancy.

Results: The prevalence of asthma requiring healthcare utilisation was 0.43% among pregnant women. Among those with asthma requiring healthcare utilisation, 6.9% were hospitalised and treated with systemic steroids and short-acting β2-agonists during pregnancy. Oral drugs were prescribed less during the third trimester than during the first trimester (all p values for trends were <0.001). A significant number of patients with asthma were likely to stop taking antiasthmatic drugs after becoming pregnant.

Conclusions: The prevalence of asthma requiring healthcare utilisation during pregnancy was not very high. However, a significant number of women were likely to stop taking antiasthmatic drugs, and those who did tended to experience exacerbations.

Keywords: EPIDEMIOLOGY; inhaled respiratory drugs; pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adrenal Cortex Hormones / therapeutic use
  • Adrenergic beta-Agonists / therapeutic use
  • Adult
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Asthma / epidemiology
  • Cohort Studies
  • Databases, Factual
  • Drug Prescriptions / statistics & numerical data*
  • Drug Therapy, Combination
  • Female
  • Hospitalization / statistics & numerical data*
  • Humans
  • Patient Acceptance of Health Care / statistics & numerical data*
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / epidemiology*
  • Pregnancy Trimesters
  • Republic of Korea

Substances

  • Adrenal Cortex Hormones
  • Adrenergic beta-Agonists
  • Anti-Asthmatic Agents