Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

Daniele Lo Re; Ying Zhou; Joanna Mucha; Leigh F Jones; Lorraine Leahy; Corrado Santocanale; Magdalena Krol; Paul V Murphy

doi:10.1002/chem.201504167

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

Chemistry. 2015 Dec 7;21(50):17993. doi: 10.1002/chem.201504167. Epub 2015 Nov 5.

Authors

Daniele Lo Re¹, Ying Zhou¹, Joanna Mucha², Leigh F Jones¹, Lorraine Leahy³, Corrado Santocanale³, Magdalena Krol², Paul V Murphy⁴

Affiliations

¹ School of Chemistry, National University of Ireland, Galway (Ireland).
² Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Science, Warsaw (Poland).
³ Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway (Ireland).
⁴ School of Chemistry, National University of Ireland, Galway (Ireland). paul.v.murphy@nuigalway.ie.

PMID: 26537992
DOI: 10.1002/chem.201504167

Abstract

Invited for the cover of this issue are Paul V. Murphy and co-workers at the National University of Ireland Galway (NUI Galway) and Warsaw University. The image depicts MGSTA-6 giving a stop signal to tumour cells that are on the move. Read the full text of the article at 10.1002/chem.201502861.

MeSH terms

Cell Line, Tumor
Cell Movement / drug effects*
Humans
Macrocyclic Compounds / chemistry*
Macrolides / chemical synthesis*
Macrolides / chemistry
Macrolides / pharmacology*
Molecular Structure
Piperidones / chemical synthesis*
Piperidones / chemistry
Piperidones / pharmacology*
Structure-Activity Relationship

Substances

Macrocyclic Compounds
Macrolides
Piperidones
migrastatin