Comparative effectiveness of lumbar epidural steroid injections using particulate vs. non-particulate steroid: an intra-individual comparative study

Skeletal Radiol. 2016 Feb;45(2):169-76. doi: 10.1007/s00256-015-2277-3. Epub 2015 Nov 5.

Abstract

Objectives: To perform an intra-individual comparison for the effectiveness of lumbar epidural steroid injection (ESI) between injections using particulate (triamcinolone) and non-particulate (dexamethasone) steroid.

Materials and methods: This study included 162 patients(M:F = 60:102, mean age 66.3 years) who underwent lumbar ESI using dexamethasone(ESI_DEXA) from April 2013 to May 2013 and who had previously underwent lumbar ESI using triamcinolone(ESI_TRIAM) within 1 year. Degree of relative satisfaction, injection-free interval and injection frequency were determined. Subgroup analyses were also done according to the diagnosis, approach-methods, patients' ages and sex.

Results: Eighty-seven of 139 patients (62.6 %) responded that the effect of ESI_TRIAM was better than that of ESI_DEXA (p = 0.004). In the four subgroups-patients with herniated intervertebral disc (HIVD), who underwent transforaminal ESI, were under age 70 and were male patients-the proportion of patients who preferred ESI_TRIAM was significantly greater than the proportion patients who preferred ESI_DEXA in terms of relative satisfaction (p < 0.05). The injection-free interval of ESI_TRIAM was significantly longer than that of ESI_DEXA (p = 0.01). In the subgroup analyses, the patient groups HIVD, who underwent transforaminal ESI, under age 70 and female patients with longer injection-free interval of ESI_TRIAM than ESI_DEXA were statistically significant (p < 0.05). Other factors were not significant.

Conclusion: The relative satisfaction with ESI_TRIAM was significantly better than that with ESI_DEXA in the same patient, and the injection-free interval after ESI_TRIAM was significantly longer than that after ESI_DEXA.

Keywords: Effectiveness; Epidural; Injection; Spine; Steroid.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Dexamethasone / administration & dosage
  • Dexamethasone / therapeutic use*
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / therapeutic use*
  • Humans
  • Injections, Epidural
  • Intervertebral Disc Displacement / complications
  • Low Back Pain / drug therapy*
  • Low Back Pain / etiology
  • Lumbar Vertebrae
  • Male
  • Treatment Outcome
  • Triamcinolone / administration & dosage
  • Triamcinolone / therapeutic use*

Substances

  • Glucocorticoids
  • Triamcinolone
  • Dexamethasone